|PRODUCT/INDICATION||PRE CLINICAL||PHASE 1||PHASE 2||PHASE 3||MARKETED|
|Serious Skin Infections (ABSSSI)
IV-ORAL FORMULATIONS (QIDP)
|Serious Community-Acquired Bacterial Pneumonia (CABP)
|Complicated Urinary Tract Infections (cUTI)
IV-ORAL (PURSUING QIDP)
|ESKAPE Pathogen Program|
- ABSSSI: Acute bacterial skin and skin structure infections || CABP: Community-acquired bacterial pneumonia || cUTI: Complicated urinary tract infections || ESKAPE: The ESKAPE pathogen is methicillin-resistant Staphylococcus aureus || QIDP: Qualified Infectious Disease Product || SPA: Special Protocol Assessment
Melinta Therapeutics’ lead therapy, Baxdela (delafloxacin), is FDA approved in the US for the treatment of serious skin infections known as acute bacterial skin and skin structure infections (ABSSSI). For more information about Baxdela for treatment of ABSSSI, please visit www.Baxdelarx.com. The Company has also initiated a Phase 3 clinical trial for serious community acquired bacterial pneumonia (CABP) and plans to develop further indications such as complicated urinary tract infections (cUTI). Click here to visit the Baxdela webpage to learn more about this investigational therapy.
Our earlier-stage pipeline includes multiple compounds in preclinical and clinical testing that have been developed to target binding sites on the bacterial ribosome. The ribosome is an essential component of all living cells, including bacteria, and translates genetic information into proteins. Ribosomes are comprised of a small (30S) and large (50S) subunit. Antibiotics work by targeting and binding to sites within either subunit of the bacterial ribosome, inhibiting protein synthesis and killing the bacteria. Our work is based on proprietary knowledge of the structure and function of the bacterial ribosome drawn from high definition X-ray crystallography, for which one of our founders, Dr. Thomas Steitz, was awarded the 2009 Nobel Prize in Chemistry because of the potential of the science to help design better, life-saving antibiotics. Our pipeline includes a family of antimicrobial compounds that were synthesized with a molecular structure specifically designed to bind to a previously untapped region of the ribosome.